Table 2 Evaluation and comparison of the performances of PEPOP

Number of clusters containing epitopic residues/total number of clusters

Number of predicted residues of the epitope

Sp

Se

PPV

Sp

Se

PPV

Sp

Se

PPV

D1.3 – hen egg lysozyme [54]

1SFG_A

10

1/4

10

0.77

1.00

0.27

0.76

1.00

0.26

0.80

0.40

0.14

D44.1 – hen egg lysozyme [56]

1T6V_M

11

1/5

11

0.81

1.00

0.33

0.78

0.91

0.28

0.86

0.55

0.27

HyHEL-5 – hen egg lysozyme [57]

1VDP_B

14

1/5

13

0.83

0.93

0.41

0.88

0.00

0.00

0.78

0.00

0.00

Jel42 – HPr [60]

1POH

16

2/8

13

0.93

0.81

0.72

0.90

0.75

0.63

0.97

0.06

0.33

D11.15 – hen egg lysozyme [55]

1HEL

10

2/5

8

0.95

0.80

0.57

0.90

0.10

0.08

0.82

0.30

0.13

5G9 – tissue factor [61]

1WV7_T

18

1/3

14

0.75

0.78

0.25

0.84

0.28

0.15

0.84

0.17

0.10

BH151 – hemagglutinin [62]

5HMG_C

19

3/7

12

0.83

0.63

0.19

0.97

0.32

0.40

0.75

0.11

0.03

Bo2C11 – FVIII C2 domain [63]

1D7P_M

15

3/5

8

0.92

0.53

0.42

0.94

0.47

0.44

0.83

0.53

0.25

NC41 – neuraminidase [64]

1NMC_N

22

3/4

11

0.90

0.50

0.23

0.99

0.59

0.81

0.85

0.64

0.20

F9.13.7 – guinea fowl lysozyme [65]

1HHL

10

3/5

5

0.98

0.50

0.71

0.92

0.50

0.33

0.83

0.40

0.17

HyHEL-10 – hen egg lysozyme [58]

1UC0_A

16

3/5

8

0.99

0.50

0.89

0.96

0.56

0.64

0.87

0.44

0.32

HyHEL-63 – hen egg lysozyme [59]

1VFB_C

23

3/4

9

0.82

0.39

0.32

0.73

0.30

0.19

0.87

0.39

0.39

N10 – staphylococcal nuclease [66]

1EYO_A

18

3/6

6

0.87

0.33

0.29

0.88

0.06

0.07

0.66

0.33

0.13

Average

0.87

0.67

0.43

0.88

0.45

0.33

0.83

0.33

0.19

Median

0.87

0.63

0.33

0.90

0.47

0.28

0.83

0.39

0.17