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Figure 3 | BMC Bioinformatics

Figure 3

From: Subfamily specific conservation profiles for proteins based on n-gram patterns

Figure 3

(a) Distribution of the similarity threshold samples for carbonic anhydrase (P00918) over the range from 20–80%. The sample contains over 200 members at the 20% level. (b) Plots of the average amplitude of reconstructions from the first and second eigenvectors for P00918. The average amplitude for the reconstruction from the first eigenvector goes from low to high as the similarity to the query increases. The reconstruction from the second eigenvector goes in the opposite direction. The amplitude is relatively flat over the 20–80% range. (c) Plot of the reconstructions using the first eigenvector for similarity ranges from 20–60%. The profile is almost invariant over this range. (d) Invariant conservation profile (ICP) for P00918 reconstructed from the 40% similarity level. The plot is shown with and without nearest-neighbor smoothing.

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