Table 1 Transmembrane helical segments of bovine rhodopsin and the number and position of transmembrane segments of hGalR1 predicted using different transmembrane prediction methods.
From: Modelling the structures of G protein-coupled receptors aided by three-dimensional validation
| Â | Method b used for predictingTMS of hGalR1 | TMS of bovine rhodopsin | |||||||
|---|---|---|---|---|---|---|---|---|---|
TMS a | DAS | HMMTOP | SOSUI | TMHMM | TopPred | TMPRED | Baldwin d | Crystal structure c | Baldwin d |
I | 32–58 | 35–59 | 31–53 | 37–59 | 33–53 | 34–58 | 38–55 | 34–64 | 38–64 |
II | 73–93 | 72–89 | 70–92 | 72–94 | 82–102 | 77–108 | 72–89 | 71–100 | 69–95 |
III | 98–129 | 110–131 | 103–125 | 109–131 | 111–131 | 110–131 | 113–130 | 106–139 | 108–142 |
IV | 153–166 | 152–171 | 151–173 | 151–173 | 151–171 | 152–172 | 155–168 | 150–173 | 151–175 |
V | 201–221 | 202–221 | 201–223 | 205–227 | 201–221 | 199–221 | 203–219 | 200–225 | 204–233 |
VI | 248–262 | 246–263 | 245–267 | 248–270 | 245–265 | 245–263 | 249–266 | 247–277 | 245–274 |
VII | 281–286 | 290–307 | 271–293 | 285–307 | 268–288 | 265–288 | 289–304 | 285–309 | 288–311 |
VIII |  |  |  |  | 286–306 |  |  | 311–320 |  |