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Figure 4 | BMC Bioinformatics

Figure 4

From: Preferential binding of allosteric modulators to active and inactive conformational states of metabotropic glutamate receptors

Figure 4

Differences in energy between active (ANM based) and inactive (rhodopsin crystal-structure based) models of mGluRs docked with the ligands shown in Figure 1 and listed in Table 1. Green bars indicate positive modulators, red bars negative modulators and the yellow bar represents a neutral ligand. Where values of 2 are shown, the ligand did not dock to the active model, where values of -2 are shown, the ligand did not dock to the inactive model. Error bars indicate standard deviation in three docking experiments each for the respective active and inactive models. If an error bar is placed at a -2 or 2 bar, the error represents the standard deviation of the ligand and model combination where docking was observed. A. Results from docking with Autodock software. B. Results from docking with ArgusLab software.

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