Figure 1

(A) Connectivity distribution for the entire molecular network; (B) Targets of the successful drugs are significantly more connected than an average gene in the network, but are not the most highly connected genes in the network; (C) Drug targets tend to have higher than average betweenness values; (D) The successful drug targets are not statistically different from the rest of the genes in terms of their clustering coefficients; (E-F): Analysis of the ratio (C _ratio ) of the number of non-synonymous to synonymous single-nucleotide polymorphisms (SNPs): (E) Successful drug targets have significantly smaller C _ratio than human genes on average. (F) The value of C _ratio tends to correlate negatively with the gene's connectivity in the network.