Finding microRNA regulatory modules in human genome using rule induction

BMC Bioinformatics

Table 3 Biological processes of potential miRNA regulatory modules annotated in GO [18]

Module	GOid	Biological processes	Target genes	P-value
1	GO:0032501	Multicellular organismal process	NOVA1, ST8SIA4, ZFP36L1	8.63E-03
	GO:0009059	Macromolecule biosynthetic process	ST8SIA4, ZFP36L1	8.19E-03
2	GO:0007166	Cell surface receptor linked signal transduction	NEDD9, BMPR2, PTPRF	7.16E-03
	GO:0019538	Protein metabolic process	DAG1, YES1, BMPR2, PTPRF	7.16E-03
	GO:0006464	Protein modification process	YES1, BMPR2, PTPRF	7.16E-03
3	GO:0010467	Gene expression	PCAF, NOVA1, EIF4A2	7.49E-03
	GO:0018076	N-terminal peptidyl-lysine acetylation	PCAF, EIF4A2	5.65E-03
4	GO:0051348	Negative regulation of transferase activity	APC, PKIA	2.48E-03
	GO:0006469	Negative regulation of protein kinase activity	APC, PKIA	2.48E-03

Biological processes of four example modules were found by GOstat program [19]. GOid is the identification of the Gene Ontology (GO) term. P-values were calculated upon assuming hyper-geometric distribution of annotated GO terms.

ISSN: 1471-2105