Motif P Value Distributions for yeast datasets. We report the number of interactions with Motif P value lower than the threshold (reported on the × axis in logarithmic scale) for the experimental datasets (blue) and for its randomized version (red). The interactions for which no motif was found are reported as bars in the origin. The Motif P value distribution for the experimental datasets contains a larger fraction of interactions with respect to the random datasets and is shifted towards lower P values. (A) BIND, (B) BioGRID, (C) Gavin06 and (D) Krogan datasets.