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Table 1 Cross-validation performance of the sequence-based SVM method as a function of different windows lengths centred on the mutated residue

From: A three-state prediction of single point mutations on protein stability changes

Method

Windows

<Q>

<C>

Q[-]

P[-]

C[-]

Q[N]

P[N]

C[N]

Q[+]

P[+]

C[+]

SVM-BASE

0

0.51

0.23

0.54

0.44

0.29

0.48

0.62

0.17

0.54

0.44

0.29

SVM-WIN25

25

0.54

0.25

0.48

0.47

0.30

0.59

0.60

0.19

0.48

0.47

0.30

SVM-WIN31

31

0.56

0.27

0.42

0.49

0.30

0.70

0.61

0.24

0.42

0.49

0.29

SVM-WIN37

37

0.54

0.25

0.46

0.47

0.29

0.62

0.61

0.21

0.46

0.47

0.29

  1. +, − and N: the indexes are evaluated for increasing , decreasing or neutral protein free energy stability change, respectively according to the classification described in section 2; for the definition of the different indexes see the System and Methods in [1214].