Figure 4

Representation of the fifteen lowest energy poses of urokinase kringle domain on αvβ3 in the closed conformation. The α and β chains of αvβ3 are shown as pale pink and yellow spheres respectively. The stretch of aminoacids homologous to α325 peptide are highlighted in magenta, homology to β1P1 is in orange, homology to β1P2 in yellow.

Ribbons represent every ligand pose after the rigid-body simulations. A spectrum of different shadows of red, green, blue, cyan were used going from lowest to highest energy solutions.