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Table 6 The example sentences of each ‘bio-inference’ scheme

From: New challenges for text mining: mapping between text and manually curated pathways

class

example

inferred reaction IDs

1

a

ex1

p50 is translated as a precursor of 105 kDa.

R10

 

b

ex2

CD23-induced NF-kappaB is a heterodimer composed of p65/p50 subunits.

R1

2

a

ex3

RelA contains a high-affinity binding site for its cytoplasmic inhibitor, I kappa B alpha.

R2

 

b

ex4

I kappa B-alpha inhibits transcription factor NF-kappa B by retaining it in the cytoplasm.

R2

3

a

ex5

When either serine- 32 or serine- 36 of I kappa B-alpha was mutated, the protein did not undergo signal-induced phosphorylation.

R3

 

b

ex6

Pretreatment of the cells with the proteasome inhibitor N-Ac-Leu-Leu-norleucinal inhibits this ligand-induced degradation of the human I kappa B alpha protein.

R5

4

 

ex7

As observed with I kappa B alpha, nuclear RelA stimulates p100 mRNA and protein expression.

R8

5

 

ex8

Nuclear expression of NF-kappa B occurs after its induced dissociation from its cytoplasmic inhibitor I kappa B alpha.

R2

6

 

ex9

A failure to degrade IkappaB-alpha pretreated with PAO is not due to its inhibitory effect on proteasomal degradation.

R5

  1. The example sentences of each class of ‘bio-inference’ scheme are shown with their inferred reaction IDs. The linguistic cues to infer some reaction are shown in boldface.