Figure 1From: Stochastic models for the in silico simulation of synaptic processesA picture of the Calyx of Held. The calyx of Held is an excitatory glutamatergic synapse in the auditory brainstem circuit. It is part of the relay pathway subserving sound-source localization. It synapses onto a given single MNTB (medial nucleus of the trapezoid body) principal cell. A gradient of Ca2+ ions in the presynaptic trait activates vesicles – five ions bind a vesicle. Activated vesicles release neurotransmitters in the synaptic cleft. Membrane channels in the postsynaptic trait react to neurotransmitters. Adapted by permission from MacMillan Publishers Ltd: Nature Neuroscience http://www.nature.com/neuro/index.html. R. Heidelberger and H. von Gersdorff "Illuminating the calcium sensor for exocytosis in a flash", 8(4), 402-404, copyright 2005.Back to article page