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Figure 12 | BMC Bioinformatics

Figure 12

From: Stochastic models for the in silico simulation of synaptic processes

Figure 12

An in silico experiment on the complete synapse model. Results about an experiment regarding a train of calcium waves at a frequency of about 100 Hz, which mimics action potentials like neural signals. In the left picture calcium waves and other variables are reported. The same data are reported in the center picture in logarithmic scale. This allows the dynamics of the many processes involved to be appreciated, such as the dynamics of the neurotransmitters and the number of open channels. In the right picture a selection of the most significant variables is reported. It can be noted, for instance, that the same amount of neurotransmitter causes different effects as far as the number of opened channels is concerned (compare the ratio between O1 and T in the first two waves with the same ratio in the sixth and the seventh wave) and, above all, a buildup of desensitization is visible starting from the fourth wave (see the increase of value D in between the third and fourth wave).

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