Membrane receptor activity. Simulation results showing the postsynaptic membrane receptor activity, which follows the release of neurotransmitters. From left to right are reported the time course of the neurotransmitter T and the channel states C0, C1, C2, O1, O2 and D, the logarithm scale of them and a focus on the time course of O1, O2 and D. Each presynaptic stochastically generated T corresponds to a wave of neurotransmitters whose duration and amplitude have been calculated on the basis of several hypotheses (see text). It can be observed the very short duration of the T wave if compared to the slower kinetics of the postsynaptic activated channels. For each T wave, the number of open channels is of the order of tens and it is also evident a buildup of the desensitization. The values of the kinetic rates were: = 400, = 1/6, = 86000, r
= 900, r
= 64, = 100000, = 2000, = 2000, = 250,C0 = 100.