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Figure 4 | BMC Bioinformatics

Figure 4

From: Drug interaction prediction using ontology-driven hypothetical assertion framework for pathway generation followed by numerical simulation

Figure 4

Inferred pathway of irinotecan. Small rectangles and ellipses are instances of continuants and molecular events, respectively. Large rectangles such as small intestine are the compartments. Molecular event and trigger, situator, and resultant were connected by solid lines. Each molecular event was connected by the shared continuants. For example, TR0000020 and TR0000002 in the small intestine were connected because they share the same instance of SN-38. This connection can be interpreted as that irinotecan is metabolized into SN-38 (TR0000020) and then SN-38 is transported to the intestinal lumen. (This figure was generated by our inference system.).

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