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Table 1 AUC and Cmax of blood concentration/time profile obtained by numerical simulations.

From: Drug interaction prediction using ontology-driven hypothetical assertion framework for pathway generation followed by numerical simulation

  Irinotecan APC NPC SN-38 SN-38G
AUCKCZ-[nmol·min/ml] 672 233 14.2 29.8 137
CmaxKCZ-[μ M] 2.22 0.290 0.0113 0.0491 0.129
AUCKCZ+[nmol·min/ml] 721 112 5.01 32.2 147
CmaxKCZ+[μ M] 2.29 0.0741 0.00228 0.0515 0.136
AUCKCZ+/AUCKCZ-[%] 107 48.1 35.3 108 107
CmaxKCZ+/CmaxKCZ-[%] 103 25.6 20.2 105 105
AUC UGT [nmol·min/ml] 672 233 14.2 62.1 85.5
Cmax UGT [μ M] 2.22 0.290 0.0113 0.0812 0.0693
AUC UGT /AUCKCZ-[%] 100 100 100 208 62.4
Cmax UGT /CmaxKCZ-[%] 100 100 100 165 53.7
  1. AUC and Cmax values for solo administration of irinotecan (AUCKCZ-, CmaxKCZ-), co-administration of irinotecan and ketoconazole (AUCKCZ+, CmaxKCZ+), and sole administration of irinotecan with patients having UGT1A1*28/*28 (AUC UGT , Cmax UGT ) were obtained.