Figure 4
From: Quantitative analysis of numerical solvers for oscillatory biomolecular system models
'Take-off point' variation for ode23 simulation under RET ('RelTol' = 10-3). The 'take-off' point is defined as the pivotal time-point when the numerical solution first departs radically from expected stable limit cycle behavior. This is determined by visual inspection of the time-series solution. Adaptive step-sizes allowed in implementation may account for the variation of the 'take-off' point with respect to the maximum step-size allowed.