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Table 1 Forward and backward procedures.

From: Clustering ionic flow blockade toggles with a Mixture of HMMs

Forward procedure

Backward procedure

α t (i) ≡ p(o1,..., o t |q t = S i , λ)

β t (i) ≡ p(ot+1,..., o T |q t = S i , λ)

• Initially α1(i) = π i b i (o1) for 1 ≤ iN,

• Initially βT(i) = 1 for 1 ≤ iN,

α t ( j ) = [ i = 1 N α t 1 ( i ) a i , j ] b j ( o t ) MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGaciGaaiaabeqaaeqabiWaaaGcbaGaeqySde2aaSbaaSqaaiabdsha0bqabaGccqGGOaakcqWGQbGAcqGGPaqkcqGH9aqpdaWadaqaamaaqadabaGaeqySde2aaSbaaSqaaiabdsha0jabgkHiTiabigdaXaqabaGccqGGOaakcqWGPbqAcqGGPaqkcqWGHbqydaWgaaWcbaGaemyAaKMaeiilaWIaemOAaOgabeaaaeaacqWGPbqAcqGH9aqpcqaIXaqmaeaacqWGobGta0GaeyyeIuoaaOGaay5waiaaw2faaiabdkgaInaaBaaaleaacqWGQbGAaeqaaOGaeiikaGIaem4Ba82aaSbaaSqaaiabdsha0bqabaGccqGGPaqkaaa@5078@ for t = 2, 3,..., T and 1 ≤ jN,

β t ( i ) = j = 1 N α i , j b j ( o t + 1 ) β t + 1 ( j ) MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGaciGaaiaabeqaaeqabiWaaaGcbaGaeqOSdi2aaSbaaSqaaiabdsha0bqabaGccqGGOaakcqWGPbqAcqGGPaqkcqGH9aqpdaaeWaqaaiabeg7aHnaaBaaaleaacqWGPbqAcqGGSaalcqWGQbGAaeqaaOGaemOyai2aaSbaaSqaaiabdQgaQbqabaGccqGGOaakcqWGVbWBdaWgaaWcbaGaemiDaqNaey4kaSIaeGymaedabeaakiabcMcaPiabek7aInaaBaaaleaacqWG0baDcqGHRaWkcqaIXaqmaeqaaOGaeiikaGIaemOAaOMaeiykaKcaleaacqWGQbGAcqGH9aqpcqaIXaqmaeaacqWGobGta0GaeyyeIuoaaaa@50B2@ for t = T - 1,...,1 and 1 ≤ iN,

• Finally p ( O | λ ) = i = 1 N α T ( i ) MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGaciGaaiaabeqaaeqabiWaaaGcbaGaemiCaaNaeiikaGIaem4ta8KaeiiFaWNaeq4UdWMaeiykaKIaeyypa0ZaaabmaeaacqaHXoqydaWgaaWcbaGaemivaqfabeaakiabcIcaOiabdMgaPjabcMcaPaWcbaGaemyAaKMaeyypa0JaeGymaedabaGaemOta4eaniabggHiLdaaaa@40DC@ is the sequence likehood.

• Finally p ( O | λ ) = i = 1 N π i b i ( o 1 ) β 1 ( i ) MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGaciGaaiaabeqaaeqabiWaaaGcbaGaemiCaaNaeiikaGIaem4ta8KaeiiFaWNaeq4UdWMaeiykaKIaeyypa0ZaaabmaeaacqaHapaCdaWgaaWcbaGaemyAaKgabeaakiabdkgaInaaBaaaleaacqWGPbqAaeqaaOGaeiikaGIaem4Ba82aaSbaaSqaaiabigdaXaqabaGccqGGPaqkcqaHYoGydaWgaaWcbaGaeGymaedabeaakiabcIcaOiabdMgaPjabcMcaPaWcbaGaemyAaKMaeyypa0JaeGymaedabaGaemOta4eaniabggHiLdaaaa@4B08@ .