Table 1 Top-10 SCAN clusters with highest p-values
From: A structural approach for finding functional modules from large biological networks
| Â | Cluster ID | P -value | GO Term | Term Freq. in Network | Term Freq. in Cluster | Cluster Size |
|---|---|---|---|---|---|---|
Biological Process | 1 | 4.45E-98 | nuclear mrna splicing, via spliceosome | 66 | 58 | 88 |
| Â | 89 | 1.01E-65 | translation | 252 | 58 | 64 |
| Â | 5 | 1.16E-52 | ubiquitin-dependent protein catabolic process | 60 | 34 | 56 |
| Â | 2 | 9.04E-40 | transcription from rna polymerase ii promoter | 50 | 41 | 288 |
| Â | 15 | 8.58E-38 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 13 | 13 | 13 |
| Â | 22 | 1.36E-30 | chromatin remodeling | 46 | 20 | 40 |
| Â | 192 | 5.46E-29 | vacuolar acidification | 23 | 13 | 16 |
| Â | 13 | 6.36E-29 | chromosome segregation | 36 | 16 | 25 |
| Â | 24 | 2.14E-28 | regulation of microtubule polymerization or depolymerization | 10 | 10 | 12 |
| Â | 30 | 9.29E-28 | regulation of cell growth | 10 | 10 | 13 |
Cellular Components | 7 | 6.81E-53 | cytosolic large ribosomal subunit | 80 | 55 | 222 |
| Â | 89 | 1.50E-51 | mitochondrial small ribosomal subunit | 33 | 29 | 64 |
|  | 1 | 2.53E-41 | u4/u6 × u5 tri-snrnp complex | 27 | 25 | 88 |
| Â | 15 | 9.01E-36 | anaphase-promoting complex | 15 | 13 | 13 |
| Â | 22 | 7.15E-31 | rsc complex | 16 | 15 | 40 |
| Â | 24 | 2.14E-28 | dash complex | 10 | 10 | 12 |
| Â | 38 | 2.14E-28 | trapp complex | 10 | 10 | 12 |
| Â | 185 | 7.18E-26 | ribonuclease mrp complex | 9 | 9 | 11 |
| Â | 155 | 5.84E-25 | smc5-smc6 complex | 8 | 8 | 8 |
| Â | 53 | 4.93E-24 | dna replication preinitiation complex | 21 | 12 | 22 |
Molecular Functions | 89 | 5.64E-71 | structural constituent of ribosome | 210 | 58 | 64 |
| Â | 5 | 2.75E-45 | endopeptidase activity | 26 | 24 | 56 |
| Â | 1 | 7.12E-45 | contributes_to rna splicing factor activity, transesterification mechanism | 29 | 27 | 88 |
| Â | 37 | 6.44E-41 | snap receptor activity | 24 | 23 | 74 |
| Â | 192 | 4.65E-28 | hydrogen ion transporting atpase activity, rotational mechanism | 12 | 11 | 16 |
| Â | 185 | 7.18E-26 | contributes_to ribonuclease mrp activity | 9 | 9 | 11 |
| Â | 22 | 6.60E-23 | contributes_to dna-dependent atpase activity | 15 | 12 | 40 |
| Â | 34 | 1.30E-22 | protein transporter activity | 24 | 14 | 46 |
| Â | 15 | 2.25E-18 | ubiquitin-protein ligase activity | 44 | 10 | 13 |
| Â | 8 | 1.37E-17 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity | 8 | 8 | 35 |