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Table 2 Top-10 CNM clusters with highest p-values

From: A structural approach for finding functional modules from large biological networks

 

Cluster ID

P -value

GO Term

Term Freq. in Network

Term Freq. in Cluster

Cluster Size

Biological Process

15

2.10E-61

nuclear mrna splicing, via spliceosome

66

55

220

 

17

5.00E-40

transposition, rna-mediated

33

19

22

 

13

5.11E-31

rna elongation from rna polymerase ii promoter

53

51

919

 

49

4.30E-25

ribosomal large subunit assembly and maintenance

39

34

549

 

16

1.09E-23

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

13

13

75

 

58

2.78E-22

microtubule nucleation

22

16

98

 

53

7.86E-20

trna processing

14

8

10

 

45

8.35E-18

negative regulation of gluconeogenesis

9

7

12

 

56

3.15E-17

ubiquitin-dependent protein catabolic process via the multivesicular body pathway

13

11

91

 

63

1.73E-13

mrna polyadenylation

17

13

241

Cellular Components

11

3.67E-66

mitochondrial large ribosomal subunit

43

41

107

 

49

4.72E-42

cytosolic large ribosomal subunit

80

64

549

 

17

5.00E-40

retrotransposon nucleocapsid

33

19

22

 

58

1.28E-30

condensed nuclear chromosome kinetochore

30

22

98

 

16

2.48E-24

anaphase-promoting complex

15

14

75

 

20

1.58E-23

peroxisomal membrane

12

9

11

 

37

9.63E-23

smc5-smc6 complex

8

8

11

 

53

2.36E-22

ribonuclease mrp complex

9

8

10

 

63

5.21E-18

mrna cleavage and polyadenylation specificity factor complex

14

14

241

 

65

3.13E-15

alpha-1,6-mannosyltransferase complex

6

6

18

Molecular Functions

17

1.71E-26

rna binding

130

19

22

 

58

2.34E-24

structural constituent of cytoskeleton

47

22

98

 

53

2.36E-22

contributes_to ribonuclease mrp activity

9

8

10

 

13

9.16E-19

dna-directed rna polymerase activity

31

30

919

 

49

6.52E-17

snorna binding

21

20

549

 

48

5.97E-13

contributes_to protein transporter activity

7

5

10

 

30

1.24E-10

nad-independent histone deacetylase activity

4

4

15

 

65

2.79E-10

contributes_to alpha-1,6-mannosyltransferase activity

4

4

18

 

33

1.34E-09

endopeptidase activity

26

24

1408

 

63

2.52E-09

contributes_to histone lysine n-methyltransferase activity (h3-k4 specific)

7

7

241