Table 1 Major functional groups overrepresented among state-change genes and corresponding overrepresented TREs. The groups are presented according to the order of significance identified by DAVID. Overrepresented TREs marked in bold are either "off-on" TFs or increased their level; regular – not present in Panomics set; italics – not present under either condition.
Functional group | Number of genes | Major Gene Ontologies | Overrepresented TREs |
|---|---|---|---|
Gene expression, RNA processing and protein synthesis | |||
12 | 73 | Transcription factors | Â |
7 | 5 | Translation initiation factors | v-Maf, SOX-9, FOXJ2, CP2, HFH-3, Elk-1, NRF-2, AREB6 |
9 | 6 | RNA processing – ribosome biogenesis | NGFI-C, GR, HNF-4, YY1, Elk-1, NRF-2, v-Myb, NF-κB, TATA, c-Myc |
11 | 8 | Zinc binding | MIF-1, Tax/CREB |
Cell signaling proteins | |||
3 | 16 | G-protein receptor | Â |
2 | 7 | GABA receptor/ion channels | N-Myc |
6 | 9 | Ion channels, K | Â |
Post-translational modification and regulatory control | |||
8 | 5 | Glycosyltransferases | Â |
10 | 28 | Kinases | CDP, CR3+HD, CRE-BP1, CCAAT |
Cell-ECM adhesion | |||
4 | 4 | Cadherins | HNF-3β, CDP CR3+HD, E2, NF-κB, USF |
Immune function associated with suppression of effector T-cells | |||
1 | 15 | Transmembrane immunoglobulin-like proteins | NF-κB, v-Maf, RSRFC4, FOXJ2, AP-1, Pax-4, USF, CDP, Brn-2 |
Transmembrane proteins of unknown significance | |||
5 | 14 | Transmembrane proteins | AP-1 |