Skip to main content

Table 3 Pathways identified for the unique VIP genes and common genes for the van't Veer dataset.

From: Very Important Pool (VIP) genes – an application for microarray-based molecular signatures

  Accession number (Symbol) Full Name Pathway name Category (e.g. disease)
Unique VIP genes AF055033 (IGFBP5) Insulin-like growth factor binding protein 5 Estrogen signaling pathway Breast cancer
    IGF signaling pathway Lung cancer
  NM_000599 (IGFBP5)   AR mediated pathway; insulin-like growth factor-1 signaling pathway Prostate cancer
    Responsive genes Ovarian cancer
  NM_000017 (ACADS) Acyl-coenzyme A dehydrogenase, C-2 to C-3 short chain Responsive genes Colon cancer
  NM_004994 (MMP9) Matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase) Heregulin, and CXCL12 signaling pathway Breast cancer
    Bombesin, IL10, IL8, TGFbeta, and HGF signaling pathway; responsive genes Prostate cancer
    Responsive genes; thrombospondin signaling pathway Pancreatic cancer
    Gastrin, HGF, and IL4 signaling pathway; integrin, and UPAR mediated pathway Colon cancer
    Responsive genes Chronic myeloid leukemia
    EGF signaling pathway; VEGF mediated pathway; responsive genes Ovarian cancer
    HGF, and IL6 signaling pathway; Responsive genes Lung cancer
  NM_001197 (BIK) BCL2-interacting killer (apoptosis-inducing) p53 mediated pathway Colon cancer
  NM_001809 (CENPA) Centromere protein A Responsive genes Lung cancer
    p21 mediated pathway Cell-cycle
  NM_002808 (PSMD2) Proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 Tat signaling pathway Acquired immuno deficiency syndrome
  NM_004336 (BUB1) BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) Spindle Checkpoint Pathway Cell-cycle
  NM_004626 (WNT11) Wingless-type MMTV integration site family, member 11 Cell-cell signaling pathway Others
    WNT receptor signaling pathway Others
  NM_004887 (CXCL14) Chemokine (C-X-C motif) ligand 14 Signal transduction pathway Others
Common genes AL050227 (PTGER3) Prostaglandin E receptor 3 (subtype EP3) Estrogen signaling pathway Breast cancer
    PGE2 mediated pathway Lung cancer
  NM_006763 (BTG2) BTG family, member 2 Estrogen signaling pathway Breast cancer
    Responsive genes Prostate cancer
    CEBP alpha mediated pathway Chronic myeloid leukemia
    Miscellaneous DNA repair
    BTG mediated pathway Cell-cycle
  NM_003862 (FGF18) Fibroblast growth factor 18 WNT signaling pathway Colon cancer
  NM_006115 (PRAME) Preferentially expressed antigen in melanoma Responsive genes Ovarian cancer
  X05610 (COL4A2) Collagen, type IV, alpha 2 Responsive genes Glioblastoma
  NM_003981 (PRC1) Protein regulator of cytokinesis 1 p21 mediated pathway Cell-cycle
  NM_006027 (EXO1) Exonuclease 1 p21 mediated pathway Cell-cycle
  NM_002811 (PSMD7) Proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 Tat signaling pathway Acquired immuno deficiency syndrome