Table 3 Pathways identified for the unique VIP genes and common genes for the van't Veer dataset.
From: Very Important Pool (VIP) genes – an application for microarray-based molecular signatures
Accession number (Symbol) | Full Name | Pathway name | Category (e.g. disease) | |
|---|---|---|---|---|
Unique VIP genes | AF055033 (IGFBP5) | Insulin-like growth factor binding protein 5 | Estrogen signaling pathway | Breast cancer |
IGF signaling pathway | Lung cancer | |||
NM_000599 (IGFBP5) | AR mediated pathway; insulin-like growth factor-1 signaling pathway | Prostate cancer | ||
Responsive genes | Ovarian cancer | |||
NM_000017 (ACADS) | Acyl-coenzyme A dehydrogenase, C-2 to C-3 short chain | Responsive genes | Colon cancer | |
NM_004994 (MMP9) | Matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase) | Heregulin, and CXCL12 signaling pathway | Breast cancer | |
Bombesin, IL10, IL8, TGFbeta, and HGF signaling pathway; responsive genes | Prostate cancer | |||
Responsive genes; thrombospondin signaling pathway | Pancreatic cancer | |||
Gastrin, HGF, and IL4 signaling pathway; integrin, and UPAR mediated pathway | Colon cancer | |||
Responsive genes | Chronic myeloid leukemia | |||
EGF signaling pathway; VEGF mediated pathway; responsive genes | Ovarian cancer | |||
HGF, and IL6 signaling pathway; Responsive genes | Lung cancer | |||
NM_001197 (BIK) | BCL2-interacting killer (apoptosis-inducing) | p53 mediated pathway | Colon cancer | |
NM_001809 (CENPA) | Centromere protein A | Responsive genes | Lung cancer | |
p21 mediated pathway | Cell-cycle | |||
NM_002808 (PSMD2) | Proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | Tat signaling pathway | Acquired immuno deficiency syndrome | |
NM_004336 (BUB1) | BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) | Spindle Checkpoint Pathway | Cell-cycle | |
NM_004626 (WNT11) | Wingless-type MMTV integration site family, member 11 | Cell-cell signaling pathway | Others | |
WNT receptor signaling pathway | Others | |||
NM_004887 (CXCL14) | Chemokine (C-X-C motif) ligand 14 | Signal transduction pathway | Others | |
Common genes | AL050227 (PTGER3) | Prostaglandin E receptor 3 (subtype EP3) | Estrogen signaling pathway | Breast cancer |
PGE2 mediated pathway | Lung cancer | |||
NM_006763 (BTG2) | BTG family, member 2 | Estrogen signaling pathway | Breast cancer | |
Responsive genes | Prostate cancer | |||
CEBP alpha mediated pathway | Chronic myeloid leukemia | |||
Miscellaneous | DNA repair | |||
BTG mediated pathway | Cell-cycle | |||
NM_003862 (FGF18) | Fibroblast growth factor 18 | WNT signaling pathway | Colon cancer | |
NM_006115 (PRAME) | Preferentially expressed antigen in melanoma | Responsive genes | Ovarian cancer | |
X05610 (COL4A2) | Collagen, type IV, alpha 2 | Responsive genes | Glioblastoma | |
NM_003981 (PRC1) | Protein regulator of cytokinesis 1 | p21 mediated pathway | Cell-cycle | |
NM_006027 (EXO1) | Exonuclease 1 | p21 mediated pathway | Cell-cycle | |
NM_002811 (PSMD7) | Proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 | Tat signaling pathway | Acquired immuno deficiency syndrome |