From: A p-Median approach for predicting drug response in tumour cells
Gene name | Biological process | Role (referred literature) |
---|---|---|
SPARC | Regulation of cell proliferation; signal transduction | SPARC is a secreted protein, acidic and rich in cysteines. It is a matrix associated protein that elicits changes in cell shape, inhibits cell cycle progression, and influences the synthesis of extracellular matrix. Clinical evidence indicates that SPARC expression correlates with tumor progression [42]. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion [43]. |
MAP1B | Microtubule bundle formation; negative regulation of intracellular transport | MAP1B interacts with a wide variety of proteins, there is growing consideration that MAP1B plays a crucial role in cytoskeleton stability and may also have a role in other cellular functions as well [44]. DAPK-1 promotes autophagy by binding to the microtubule-associated protein MAP1B, which is an LC3 interactor with anti-autophagic functions [45]. |
DNAJA3 | Apoptosis; cell death; negative regulation of cell proliferation | It is an important cell death regulator and could exert tumor suppressor activity [46]. The results establish DNAJA3 as a novel regulator of p53-mediated apoptosis, and suggest that therapies designed to enhance DNAJA3’s function in promoting mitochondrial localization of p53 and apoptosis could be an effective therapy in many cancers [47]. |
SGK1 | Apoptosis | SGK1 is a downstream target of cell survival and that it is primarily regulated at the level of transcription [48],[49]. |
ELF3 | Inflammatory response; | Transcriptional inhibition of ELF3 could be a one of the mechanisms of colonic carcinogenesis [50]. |
CDKN2A | Cell cycle arrest; cell cycle checkpoint; negative regulation of cell growth; negative regulation of cell proliferation | CDKN2A is an important tumor suppressor gene and is specifically required for p53 activation under oncogenic stress [51]. Suppression of CDKN2A, a cell-cycle regulator, occurs in essentially all common human cancers [52]. Inactivating these tumor suppressors directly promotes tumorigenesis due to lack of control over cellular processes [53]. |
SPINT2 | Cellular component movement | SPINT2 play important roles in controlling the aggressive nature and spread of cancer, displaying a unique therapeutic potential [54]. |
GJA1 | Apoptosis | GJA1 is involved in several kinds of tumor, as breast, lung, prostate and ovarian [55],[56] and [57]. |
AKT3 | Signal transduction | AKT signaling pathway is activated in human cancers and consequences for molecularly targeted therapies. AKT isoform may play a positive or negative role in cell migration and invasion. AKT is also involved in regulation of tumor angiogenesis [58]. |
EpCAM | Positive regulation of cell proliferation | EpCAM has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway [59]. Regulated intramembrane proteolysis activates EpCAM as a mitogenic signal transducer in vitro and in vivo [60]. |