Table 4 Gene selection (CFS) based on consensus p-Median on the Sherf dataset
From: A p-Median approach for predicting drug response in tumour cells
Gene name | Biological process | Role (referred literature) |
|---|---|---|
POLR2F | Protein kinase activity; DNA binding | POLR2F exhibited elevated levels in carcinomas compared to normal tissue samples suggesting a possible role for these molecules in colorectal cancer [61]. |
SPARC | Regulation of cell proliferation; signal transduction | SPARC is a secreted protein, acidic and rich in cysteines. It is a matrix associated protein that elicits changes in cell shape, inhibits cell cycle progression, and influences the synthesis of extracellular matrix. Clinical evidence indicates that SPARC expression correlates with tumor progression [42]. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion [43]. |
DNAJA3 | Apoptosis; cell death; negative regulation of cell proliferation | It is an important cell death regulator and could exert tumor suppressor activity [46]. The results establish DNAJA3 as a novel regulator of p53-mediated apoptosis, and suggest that therapies designed to enhance DNAJA3’s function in promoting mitochondrial localization of p53 and apoptosis could be an effective therapy in many cancers [47]. |
PTN | Regulation of cell proliferation and division | PTN is an angiogenic factor and has been found to be constitutively expressed in many human tumors of different cell types [62]. |
AIF-1 | Regulation of muscle cell proliferation | AIF-1 can promote the growth of breast tumors via activating NF-kappaB signaling [63]. |
STMN4 | Regulation of microtubule polymerization or depolymerization | - |
PSAP | Lipid BINDING | PSAP is involved in prostate cancer invasion [64] and inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and Tsp-1 [65]. |
AKT3 | Signal transduction | AKT signaling pathway is activated in human cancers and consequences for molecularly targeted therapies. AKT isoform may play a positive or negative role in cell migration and invasion. AKT is also involved in regulation of tumor angiogenesis [58]. |
FBXO7 | Cell death; protein binding | - |
P4HA2 | L-ascorbic acid binding | Overexpression of PRDX4 and P4HA2 was significantly associated with lymphatic metastasis in oral cavity squamous cell carcinoma [66]. P4HA2 was upregulated in breast tumor cells compared with its adjacent normal tissues [67]. |