Figure 2

ROC curves evaluation for three levels of AS ratio when two groups of samples have the different dispersion pattern. ROC curves for eight selected methods in simulation studies ${\text{High}}_{\text{100x}}^{\text{Diff}}$ (left panel), ${\text{Medium}}_{\text{100x}}^{\text{Diff}}$ (middle panel), ${\text{Low}}_{\text{100x}}^{\text{Diff}}$ (right panel). These ROC curves are obtained at a simple size of 3 for each condition. When the level or degree of DS across conditions become smaller (panel left-right), the power of discrimination of true-DS and non-DS drops significantly. However the relative ranking of each methods tend to be unchanged. DEXSeq perform consistently the best with respect to all three simulation studies.