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Table 1 Top-25 age-associated genes with increased expression level (Van den Akker et al. [19])

From: A fast algorithm for determining bounds and accurate approximate p-values of the rank product statistic for replicate experiments

Symbol

GeneID

ρ

  

p -value

  
   

Exact

Gamma

Upper bound

Geometric mean

Lower bound

GPR56

9289

9282

2.645 × 10-10

5.255 × 10-09

3.888 × 10-10

2.709 × 10-10

1.887 × 10-10

HF1

3075

48576

2.074 × 10-09

2.296 × 10-08

2.873 × 10-09

2.117 × 10-09

1.559 × 10-09

SYT11

23208

57600

2.550 × 10-09

2.671 × 10-08

3.510 × 10-09

2.601 × 10-09

1.927 × 10-09

ARP10

164668

179400

9.817 × 10-09

7.297 × 10-08

1.303 × 10-08

1.000 × 10-08

7.680 × 10-09

B3GAT1(CD57)

27087

278460

1.635 × 10-08

1.075 × 10-07

2.142 × 10-08

1.666 × 10-08

1.295 × 10-08

SLC1A7

6512

483780

3.078 × 10-08

1.746 × 10-07

3.970 × 10-08

3.135 × 10-08

2.476 × 10-08

IFNG

3458

1594440

1.171 × 10-07

4.953 × 10-07

1.465 × 10-07

1.192 × 10-07

9.697 × 10-08

DSCR1L1

10231

2004864

1.507 × 10-07

6.046 × 10-07

1.874 × 10-07

1.533 × 10-07

1.254 × 10-07

ARK5

9891

2726880

2.110 × 10-07

7.898 × 10-07

2.605 × 10-07

2.146 × 10-07

1.768 × 10-07

PIG13

81563

3549314

2.809 × 10-07

9.927 × 10-07

3.448 × 10-07

2.857 × 10-07

2.367 × 10-07

SPUVE

11098

3880576

3.093 × 10-07

1.072 × 10-06

3.789 × 10-07

3.146 × 10-07

2.612 × 10-07

PDGFRB

5159

4294368

3.451 × 10-07

1.171 × 10-06

4.217 × 10-07

3.509 × 10-07

2.920 × 10-07

EDG8

53637

5083584

4.137 × 10-07

1.355 × 10-06

5.037 × 10-07

4.207 × 10-07

3.513 × 10-07

MARLIN1

152789

5505984

4.507 × 10-07

1.451 × 10-06

5.477 × 10-07

4.582 × 10-07

3.833 × 10-07

TGFBR3

7049

8081700

6.784 × 10-07

2.021 × 10-06

8.176 × 10-07

6.896 × 10-07

5.815 × 10-07

GZMB

3002

9886240

8.396 × 10-07

2.404 × 10-06

1.008 × 10-06

8.533 × 10-07

7.227 × 10-07

DEFA3

1168

9980528

8.481 × 10-07

2.423 × 10-06

1.018 × 10-06

8.619 × 10-07

7.301 × 10-07

KRT1

3848

11787930

1.010 × 10-06

2.796 × 10-06

1.208 × 10-06

1.027 × 10-06

8.728 × 10-07

CX3CR1

1524

12060288

1.035 × 10-06

2.851 × 10-06

1.237 × 10-06

1.052 × 10-06

8.944 × 10-07

STYK1

55359

14337372

1.241 × 10-06

3.308 × 10-06

1.477 × 10-06

1.260 × 10-06

1.076 × 10-06

ADRB2

154

16272900

1.416 × 10-06

3.687 × 10-06

1.681 × 10-06

1.438 × 10-06

1.231 × 10-06

GAF1

26056

35217600

3.138 × 10-06

7.128 × 10-06

3.667 × 10-06

3.186 × 10-06

2.769 × 10-06

CTSL

1514

38246400

3.414 × 10-06

7.647 × 10-06

3.982 × 10-06

3.465 × 10-06

3.016 × 10-06

GFI1

2672

56960480

5.107 × 10-06

1.072 × 10-05

5.907 × 10-06

5.183 × 10-06

4.547 × 10-06

TTC38

55020

59340600

5.322 × 10-06

1.110 × 10-05

6.150 × 10-06

5.400 × 10-06

4.742 × 10-06

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BMC Bioinformatics

ISSN: 1471-2105

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