Figure 2

Effects of phenotypic similarity cutoff variations on the number of elements and Jaccard coefficients. Computed phenotypic similarities for gene pairs (blue squares), OMIM disease pairs (red circles) and Orphanet disease pairs (green triangles) were filtered at the 95^th percentile, and different cutoff scores corresponding to the 95^th, 98^th, 99^th and 99.5^th percentiles were used. The Resnik and Robinson measurements are shown as solid and dashed lines, respectively. A: Variations in the number of genes and diseases that are involved in phenotypic similarities at increasing values of the similarity score. B: Variations of the Jaccard's similarity coefficients calculated from the resulting intersection between the phenotypic similarity-based networks and their respective inferred networks is represented as the distinct similarity scores.