Efficient prediction of human protein-protein interactions at a global scale

BMC Bioinformatics

Table 3 Statistical performance metrics for MP-PIPE based on true negatives (TN), true positives (TP), false negatives (FN), and false positives (FP) seen in the leave-one-out cross-validation tests, corrected to use a positive: negative ratio of 1:100

Statistical measure	Definition	Value
Specificity (True Negative Rate)	$\frac{T N}{F P + T N}$	0.9995
Sensitivity/Recall (True Positive Rate)	$\frac{T P}{T P + F N}$	0.2300
Precision	$\frac{T P}{T P + F P}$	0.8214
Accuracy	$\frac{T P + T N}{T P + F P + F N + T N}$	0.9919
F1 Score	$\frac{2 T P}{2 T P + F P + F N}$	0.3594
Matthews correlation coefficient	$\frac{TPxTN - FPxFN}{\sqrt{(T P + F P) (T P + F N) (T N + F P) (T N + F N)}}$	0.4322

ISSN: 1471-2105