Table 5 Significant pathways and constituent genes identified by the proposed DIGS model for Pawitan
Pathway name | Significant constituent genes |
|---|---|
PROSTATE CANCER | EGFR, TCF7L1, GSTP1, PDGFRA, CCNE1, CHUK, PIK3R3, ERBB2, PIK3R1 |
UBIQUITIN MEDIATED PROTEOLYSIS | UBE2E3, MID1, SKP2, BRCA1, WWP1 |
WNT SIGNALING PATHWAY | FZD7, SOX17, TCF7L1, SKP1, SFRP1, FZD8 |
O GLYCAN BIOSYNTHESIS | GALNT3, GALNT7, GALNT11, GALNT6, GCNT3, B4GALT5, GALNT8, C1GALT1, GALNT12, GCNT4, GALNT14, GALNT10, GALNT2, ST3GAL2, GCNT1, ST3GAL1, C1GALT1C1, GALNT1 |
ADHERENS JUNCTION | EGFR, ERBB2, TCF7L1, TCF7L2, MET, RAC3, SMAD3, MLLT4, RHOA |
ERBB SIGNALING PATHWAY | EGFR, NCK2, ERBB2, AKT3, PAK4, EREG, MAPK9, AKT2 |
NITROGEN METABOLISM | CA12, CA5A, CA9, GLUL, CA3, CA14, CA8, CA7, CA5B, GLUD1, CA2, AMT, CA6, CA1, CTH, GLS2, GLUD2, HAL, CA4, ASNS, CPS1 |
DORSO VENTRAL AXIS FORMATION | EGFR, NOTCH1, GRB2, MAPK3, NOTCH3, SOS1, CPEB1, PIWIL2 ETS2, MAPK1, NOTCH4, ETV6, PIWIL1, MAP2K1, NOTCH2, SOS2, ETS1, ETV7, KRAS |
ENDOMETRIAL CANCER | EGFR, TCF7L1, ERBB2, TCF7L2, MLH1, ELK1, NRAS, AKT3, ARAF, CTNNA2, PIK3CB, AKT2, CCND1, FOXO3, LEF1 |
NON SMALL CELL LUNG CANCER | EGFR, AKT3, E2F3, ERBB2, BAD, E2F1, RARB, CDKN2A, PLCG2, GRB2, HRAS, MAPK3, PIK3CD, RXRG, TGFA |
PANCREATIC CANCER | EGFR, ERBB2, AKT3, CDKN2A, MAPK9, PLD1, RAC3, RALA, CCND1, E2F3, JAK1, PIK3R1 |