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Figure 4 | BMC Bioinformatics

Figure 4

From: Improving statistical inference on pathogen densities estimated by quantitative molecular methods: malaria gametocytaemia as a case study

Figure 4

Variability of Plasmodium falciparum gametocyte density reliability estimates from quantitative nucleic acid sequence-based amplification (QT-NASBA). The boxes surrounded by dashed lines and solid lines depict, respectively, the distribution of assay-specific gametocyte density posterior standard deviations (analogous to, and labelled as, frequentist standard errors, SEs) derived from the 12 individually-fitted homoscedastic linear models (HoLMs) and the heteroscedastic linear mixed model (HeLMM). Boxes span from the 25th to the 75th percentiles (the interquartile range) of the estimated SEs and whiskers a further 1.5 × the interquartile range. Points outside of this range are indicated and horizontal bars (broken and solid) denote the medians. Boxes shaded dark grey and light grey correspond to, respectively, estimates derived from a single time to positivity (TTP) observation (m = 1) or the mean of 3 TTP observations (m = 3).

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