From: Methodology for the inference of gene function from phenotype data
Assessment | |||||||
---|---|---|---|---|---|---|---|
Rule type | Rule number | Phenotype terms included or excluded in rule | Implied GO term | p-value | O = obvious | ||
Plus-rule | MP 1+ | MP 2+ | GO | S = subtle | |||
Plus-rule | 0 | impaired ovarian folliculogenesis | absent mature ovarian follicles | ovarian follicle development | 1.47E-36 | O | |
Plus-rule | 5 | absent Peyer's patches | abnormal spleen morphology | lymph node development | 6.82E-30 | S | |
Plus-rule | 21 | abnormal direction of heart looping | situs inversus | determination of left/right symmetry | 1.53E-23 | O | |
Minus-rule | MP 1 + | MP 2 - | GO | ||||
Minus-rule | 5 | abnormal sperm flagellum morphology | asthenozoospermia | fertilization | 2.70E-26 | S | |
Minus-rule | 6 | abnormal incus morphology | abnormal temporal bone morphology | middle ear morphogenesis | 1.45E-25 | O | |
Minus-rule | 227 | failure of vascular branching | embryonic growth retardation | regulation of angiogenesis | 2.49E-10 | S | |
Plus-Plus-rule | MP 1 + | MP 2 + | MP 3 + | GO | |||
Plus-Plus-rule | 109 | increased kidney apoptosis | dilated renal tubules | increased kidney cell proliferation | negative regulation of apoptotic process | 1.83E-20 | O |
Plus-Plus-rule | 1188 | enlarged liver | hepatic necrosis | increased glycogen level | glycogen metabolic process | 1.95E-14 | S |
Plus Minus-rule | MP 1 + | MP 2 + | MP 3 - | GO | |||
Plus Minus-rule | 0 | globozoospermia | male infertility | absent acrosome | spermatogenesis | 4.21E-39 | O |
Plus Minus-rule | 309 | abnormal sperm principal piece morphology | male infertility | abnormal sperm axoneme morphology | spermatid development | 5.38E-16 | O |
Minus-Minus-rule | MP 1 + | MP 2 - | MP 3 - | GO | |||
Minus-Minus-rule | 0 | absent mature ovarian follicles | postnatal growth retardation | abnormal female reproductive system morphology | ovarian follicle development | 1.10E-31 | O |
Minus-Minus-rule | 8 | abnormal lysosome morphology | decreased embryo size | abnormal neuron morphology | lysosome organization | 1.91E-29 | O |