From: Methodology for the inference of gene function from phenotype data
 | Assessment | ||||||
---|---|---|---|---|---|---|---|
Rule type | Rule number | Phenotype terms included or excluded in rule | Implied GO term | p-value | O = obvious | ||
Plus-rule |  | MP 1+ | MP 2+ |  | GO |  | S = subtle |
Plus-rule | 0 | impaired ovarian folliculogenesis | absent mature ovarian follicles | Â | ovarian follicle development | 1.47E-36 | O |
Plus-rule | 5 | absent Peyer's patches | abnormal spleen morphology | Â | lymph node development | 6.82E-30 | S |
Plus-rule | 21 | abnormal direction of heart looping | situs inversus | Â | determination of left/right symmetry | 1.53E-23 | O |
Minus-rule | Â | MP 1 + | MP 2 - | Â | GO | Â | Â |
Minus-rule | 5 | abnormal sperm flagellum morphology | asthenozoospermia | Â | fertilization | 2.70E-26 | S |
Minus-rule | 6 | abnormal incus morphology | abnormal temporal bone morphology | Â | middle ear morphogenesis | 1.45E-25 | O |
Minus-rule | 227 | failure of vascular branching | embryonic growth retardation | Â | regulation of angiogenesis | 2.49E-10 | S |
Plus-Plus-rule | Â | MP 1 + | MP 2 + | MP 3 + | GO | Â | Â |
Plus-Plus-rule | 109 | increased kidney apoptosis | dilated renal tubules | increased kidney cell proliferation | negative regulation of apoptotic process | 1.83E-20 | O |
Plus-Plus-rule | 1188 | enlarged liver | hepatic necrosis | increased glycogen level | glycogen metabolic process | 1.95E-14 | S |
Plus Minus-rule | Â | MP 1 + | MP 2 + | MP 3 - | GO | Â | Â |
Plus Minus-rule | 0 | globozoospermia | male infertility | absent acrosome | spermatogenesis | 4.21E-39 | O |
Plus Minus-rule | 309 | abnormal sperm principal piece morphology | male infertility | abnormal sperm axoneme morphology | spermatid development | 5.38E-16 | O |
Minus-Minus-rule | Â | MP 1 + | MP 2 - | MP 3 - | GO | Â | Â |
Minus-Minus-rule | 0 | absent mature ovarian follicles | postnatal growth retardation | abnormal female reproductive system morphology | ovarian follicle development | 1.10E-31 | O |
Minus-Minus-rule | 8 | abnormal lysosome morphology | decreased embryo size | abnormal neuron morphology | lysosome organization | 1.91E-29 | O |