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Table 3 Validation of annotations derived from minus-rules

From: Methodology for the inference of gene function from phenotype data

Rule number Gene Phenotype Terms included in rule Implied GO term   
   MP 1+ MP 2- GO p-value Valid?
0 Fn1 abnormal vitelline vascular remodeling complete embryonic lethality during organogenesis angiogenesis 2.86E-41 yes
1 Gja1 absent mature ovarian follicles postnatal growth retardation ovarian follicle development 8.95E-32 yes
1 Stra8 absent mature ovarian follicles postnatal growth retardation ovarian follicle development 8.95E-32 yes
2 Ppp1cc globozoospermia absent acrosome spermatogenesis 8.65E-28 yes
4 Tert thoracic vertebral transformation cervical vertebral transformation anterior/posterior pattern specification 2.45E-26 yes
4 Kat2a thoracic vertebral transformation cervical vertebral transformation anterior/posterior pattern specification 2.45E-26 yes
5 Krt19 abnormal sperm flagellum morphology asthenozoospermia fertilization 2.70E-26 no
5 Akap4 abnormal sperm flagellum morphology asthenozoospermia fertilization 2.70E-26 no
6 Emx2 abnormal incus morphology abnormal temporal bone morphology middle ear morphogenesis 1.45E-25 yes
7 Lmx1a head tossing circling auditory receptor cell stereocilium organization 1.02E-24 no
8 Bmp7 palatal shelves fail to meet at midline cleft secondary palate thyroid gland development 1.37E-23 no
214 Sctr decreased urine sodium level decreased body weight negative regulation of blood pressure 3.25E-11 no
217 Fbn1 abnormal intercostal muscle morphology respiratory failure somitogenesis 5.27E-11 no
218 Krt19 short sperm flagellum asthenozoospermia cilium morphogenesis 5.46E-11 yes
220 Rab38 abnormal pulmonary acinus morphology respiratory distress lung development 5.84E-11 no
224 Ube2b abnormal double-strand DNA break repair small testis synapsis 1.33E-10 yes
227 Adam10 failure of vascular branching embryonic growth retardation regulation of angiogenesis 2.49E-10 no
229 Casr decreased circulating calcium level postnatal growth retardation calcium ion transport 4.98E-10 no
230 Hes7 abnormal sacral vertebrae morphology complete neonatal lethality embryonic skeletal system development 5.26E-10 yes
231 Bhlhe22 abnormal corticospinal tract morphology complete neonatal lethality adult walking behavior 5.26E-10 no