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Table 4 Validation of annotations derived from plus-plus-rules

From: Methodology for the inference of gene function from phenotype data

Rule number Gene Phenotype terms included in rule Implied GO term   
   MP 1+ MP 2+ MP 3 + GO p-value Valid?
0 Foxl2 absent mature ovarian follicles impaired ovarian folliculogenesis decreased uterus weight ovarian follicle development 4.15E-37 yes
0 Fads2 absent mature ovarian follicles impaired ovarian folliculogenesis decreased uterus weight ovarian follicle development 4.15E-37 yes
0 Kiss1 absent mature ovarian follicles impaired ovarian folliculogenesis decreased uterus weight ovarian follicle development 4.15E-37 yes
6 Mapk6 decreased lung weight small lung pulmonary hypoplasia lung development 9.35E-31 yes
17 Kiss1r decreased uterus weight decreased ovary weight decreased uterus weight ovarian follicle development 1.11E-27 yes
17 Esr1 decreased uterus weight decreased ovary weight decreased uterus weight ovarian follicle development 1.11E-27 no
22 Ndrg2 sacral vertebral transformation lumbar vertebral transformation sacral vertebral transformation anterior/posterior pattern specification 3.92E-27 yes
27 Gmcl1 abnormal acrosome morphology abnormal sperm flagellum morphology arrest of spermiogenesis acrosome assembly 2.48E-24 yes
28 Gdf6 abnormal middle ear ossicle morphology abnormal middle ear morphology abnormal stapes morphology middle ear morphogenesis 7.47E-24 yes
48 Gucy2d abnormal olfactory system physiology abnormal odor adaptation abnormal olfactory system physiology sensory perception of smell 4.15E-22 yes
83 Tnfrsf11b abnormal middle ear ossicle morphology abnormal middle ear morphology abnormal incus morphology middle ear morphogenesis 6.33E-21 yes
109 Bag6 increased kidney apoptosis dilated renal tubules increased kidney cell proliferation negative regulation of apoptotic process 1.83E-20 yes
150 Mns1 kinked sperm flagellum oligozoospermia hairpin sperm flagellum spermatid development 4.96E-20 yes
719 Pou1f1 abnormal cerebellar foliation tremors abnormal cerebellar granule layer neuron migration 5.59E-16 yes
763 Prdm9 abnormal double-strand DNA break repair abnormal ovary morphology decreased oocyte number double-strand break repair 8.50E-16 yes
812 Camk4 increased bone mineral density decreased osteoclast cell number failure of tooth eruption ossification 1.27E-15 no
814 Ddr2 decreased circulating testosterone level absent corpus luteum Leydig cell hypoplasia spermatogenesis 1.31E-15 yes
816 Bmper curly tail short tail abnormal rib-vertebral column attachment skeletal system morphogenesis 1.33E-15 yes
1373 Sec61a1 enlarged liver increased circulating triglyceride level increased glycogen level glycogen metabolic process 6.61E-14 no
1709 Ctsc decreased circulating interleukin-6 level decreased susceptibility to endotoxin shock decreased circulating interleukin-6 level response to lipopolysaccharide 4.38E-13 no
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