Table 4 Validation of annotations derived from plus-plus-rules

0

Foxl2

absent mature ovarian follicles

impaired ovarian folliculogenesis

decreased uterus weight

ovarian follicle development

4.15E-37

yes

0

Fads2

absent mature ovarian follicles

impaired ovarian folliculogenesis

decreased uterus weight

ovarian follicle development

4.15E-37

yes

0

Kiss1

absent mature ovarian follicles

impaired ovarian folliculogenesis

decreased uterus weight

ovarian follicle development

4.15E-37

yes

6

Mapk6

decreased lung weight

small lung

pulmonary hypoplasia

lung development

9.35E-31

yes

17

Kiss1r

decreased uterus weight

decreased ovary weight

decreased uterus weight

ovarian follicle development

1.11E-27

yes

17

Esr1

decreased uterus weight

decreased ovary weight

decreased uterus weight

ovarian follicle development

1.11E-27

no

22

Ndrg2

sacral vertebral transformation

lumbar vertebral transformation

sacral vertebral transformation

anterior/posterior pattern specification

3.92E-27

yes

27

Gmcl1

abnormal acrosome morphology

abnormal sperm flagellum morphology

arrest of spermiogenesis

acrosome assembly

2.48E-24

yes

28

Gdf6

abnormal middle ear ossicle morphology

abnormal middle ear morphology

abnormal stapes morphology

middle ear morphogenesis

7.47E-24

yes

48

Gucy2d

abnormal olfactory system physiology

abnormal odor adaptation

abnormal olfactory system physiology

sensory perception of smell

4.15E-22

yes

83

Tnfrsf11b

abnormal middle ear ossicle morphology

abnormal middle ear morphology

abnormal incus morphology

middle ear morphogenesis

6.33E-21

yes

109

Bag6

increased kidney apoptosis

dilated renal tubules

increased kidney cell proliferation

negative regulation of apoptotic process

1.83E-20

yes

150

Mns1

kinked sperm flagellum

oligozoospermia

hairpin sperm flagellum

spermatid development

4.96E-20

yes

719

Pou1f1

abnormal cerebellar foliation

tremors

abnormal cerebellar granule layer

neuron migration

5.59E-16

yes

763

Prdm9

abnormal double-strand DNA break repair

abnormal ovary morphology

decreased oocyte number

double-strand break repair

8.50E-16

yes

812

Camk4

increased bone mineral density

decreased osteoclast cell number

failure of tooth eruption

ossification

1.27E-15

no

814

Ddr2

decreased circulating testosterone level

absent corpus luteum

Leydig cell hypoplasia

spermatogenesis

1.31E-15

yes

816

Bmper

curly tail

short tail

abnormal rib-vertebral column attachment

skeletal system morphogenesis

1.33E-15

yes

1373

Sec61a1

enlarged liver

increased circulating triglyceride level

increased glycogen level

glycogen metabolic process

6.61E-14

no

1709

Ctsc

decreased circulating interleukin-6 level

decreased susceptibility to endotoxin shock

decreased circulating interleukin-6 level

response to lipopolysaccharide

4.38E-13

no