From: Methodology for the inference of gene function from phenotype data
Rule number | Gene | Phenotype terms included in rule | Implied GO term | Â | Â | ||
---|---|---|---|---|---|---|---|
 |  | MP 1+ | MP 2+ | MP 3 - | GO | p-value | Valid? |
0 | M1ap | globozoospermia | male infertility | absent acrosome | spermatogenesis | 4.21E-39 | yes |
0 | Ing2 | globozoospermia | male infertility | absent acrosome | spermatogenesis | 4.21E-39 | yes |
1 | Cdk16 | abnormal sperm flagellum morphology | male infertility | teratozoospermia | cilium morphogenesis | 1.71E-28 | yes |
8 | Adipor2 | abnormal glucose homeostasis | decreased circulating insulin level | increased insulin sensitivity | positive regulation of insulin secretion | 1.49E-24 | yes |
10 | Steap3 | polychromatophilia | decreased hemoglobin content | anisocytosis | skeletal system morphogenesis | 4.46E-24 | no |
13 | Ptges3 | abnormal production of surfactant | atelectasis | cyanosis | lung alveolus development | 8.94E-24 | yes |
19 | Mbl1 | increased IgG2a level | increased IgG1 level | abnormal T cell physiology | negative regulation of B cell proliferation | 5.82E-23 | no |
47 | Kat2a | decreased body size | exencephaly | domed cranium | neural tube closure | 3.40E-20 | yes |
77 | Siglec1 | decreased tumor necrosis factor secretion | decreased interleukin-6 secretion | abnormal macrophage physiology | cellular response to lipopolysaccharide | 2.95E-19 | yes |
96 | Chga | dilated heart left ventricle | heart left ventricle hypertrophy | absent caveolae | heart morphogenesis | 1.56E-18 | no |
118 | Mark3 | improved glucose tolerance | decreased circulating insulin level | abnormal glucose homeostasis | response to insulin | 3.83E-18 | no |
124 | Gpr64 | kinked sperm flagellum | teratozoospermia | hairpin sperm flagellum | fertilization | 5.57E-18 | no |
139 | Pick1 | abnormal acrosome morphology | asthenozoospermia | absent acrosome | spermatogenesis | 8.55E-18 | yes |
153 | Col2a1 | abnormal long bone metaphysis morphology | abnormal long bone epiphyseal plate proliferative zone | protruding tongue | bone morphogenesis | 1.35E-17 | yes |
167 | Odf1 | male infertility | impaired acrosome reaction | impaired fertilization | acrosome reaction | 1.91E-17 | yes |
177 | Cftr | absent estrous cycle | small ovary | increased follicle stimulating hormone level | spermatogenesis | 2.26E-17 | no |
262 | Zfpm1 | abnormal common myeloid progenitor cell morphology | extramedullary hematopoiesis | decreased B cell number | T cell differentiation | 1.81E-16 | no |
309 | Gpx4 | abnormal sperm principal piece morphology | male infertility | abnormal sperm axoneme morphology | spermatid development | 5.38E-16 | yes |
331 | Pank1 | increased body weight | hepatic steatosis | abnormal abdominal fat pad morphology | lipid metabolic process | 7.25E-16 | yes |
391 | Cd36 | increased circulating triglyceride level | abnormal glucose homeostasis | insulin resistance | glycogen metabolic process | 2.72E-15 | no |