The output from Kiwi in case study 1, metabolic changes upon transformation to lung adenocarcinoma. (a) The Kiwi network shows the significant gene-sets and their general direction of change. Up-regulation: red, down-regulation: blue. Two metabolically connected pathways emerge, a pattern that is not easily detected in (b) a traditional heatmap or (c) a gene-overlap network. Green and orange indicate gene-sets of the two pathways, respectively. (d) The Kiwi heatmap displays the individual gene-level statistics for each significant gene-set. It also clusters similar gene-sets based on gene overlap in order to identify driver genes or potential bias.