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Figure 2 | BMC Bioinformatics

Figure 2

From: Mammalian transcriptional hotspots are enriched for tissue specific enhancers near cell type specific highly expressed genes and are predicted to act as transcriptional activator hubs

Figure 2

Hotspots preferentially bind in cell type-specific gene neighbourhoods. A. A heatmap of Pearson’s correlation coefficients of genes in 30 sets (three groups of 10 cell types) with a hierarchical clustering tree showing that singletons and combinatorials clustered together in a tight cluster while hotspot gene sets were very distinct from each other. B. Fraction of ES super enhancers defined by Whyte et al. [11] in three groups showing hotspots significantly overlapped with super enhancers. C. Fraction of high Oct4 bound regions in Oct4+/− compared to Oct4+/+ [12] ES cells in three groups showing hotspots enriched for high Oct4 bound regions in Oct4+/− and also pluripotent genes D. Functional enrichments of hotspot genes in 10 cell types along with p values showing that hotspot genes were enriched for cell type specific genes.

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