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Figure 3 | BMC Bioinformatics

Figure 3

From: Mammalian transcriptional hotspots are enriched for tissue specific enhancers near cell type specific highly expressed genes and are predicted to act as transcriptional activator hubs

Figure 3

Hotspots are enriched for sequence motifs of multiple transcription factors. A. Bar graphs of fraction of peaks with a given sequence motif in the three groups (singletons – red, combinatorials - green, hotspots - blue) with the name of the sequence motif along with the sequence in IUPAAC format for three representative motifs for each of B cells, erythroid and HPCs (see Additional file 1: Figure S1 for the complete list of motifs). B. A table of cell type, transcription-related factors analysed by ChIP sequencing, transcription-related factors binding to more than 90% of hotspot peaks and statistically significant known sequence motifs found in hotspots for B cells, erythroid and HPCs (see Additional file 1: Figure S2 for the complete table with 10 cell types).

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