Hotspots are enriched for sequence motifs of multiple transcription factors. A. Bar graphs of fraction of peaks with a given sequence motif in the three groups (singletons – red, combinatorials - green, hotspots - blue) with the name of the sequence motif along with the sequence in IUPAAC format for three representative motifs for each of B cells, erythroid and HPCs (see Additional file 1: Figure S1 for the complete list of motifs). B. A table of cell type, transcription-related factors analysed by ChIP sequencing, transcription-related factors binding to more than 90% of hotspot peaks and statistically significant known sequence motifs found in hotspots for B cells, erythroid and HPCs (see Additional file 1: Figure S2 for the complete table with 10 cell types).