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Figure 5 | BMC Bioinformatics

Figure 5

From: Mammalian transcriptional hotspots are enriched for tissue specific enhancers near cell type specific highly expressed genes and are predicted to act as transcriptional activator hubs

Figure 5

ES hotspots are preferentially occupied by activators. A. Overlap of genes in three groups in ES Ng dataset with up- and down-regulated genes upon Oct4 knockdown in ES cells showing hotspots were enriched for only down-regulated genes. B. Fraction of up- and down-regulated genes upon Dnmt and Set1db knock out in three groups in ES Ng dataset showing hotspot enrichment only in Set1db KO down-regulated genes.

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BMC Bioinformatics

ISSN: 1471-2105

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