Figure 5From: Mammalian transcriptional hotspots are enriched for tissue specific enhancers near cell type specific highly expressed genes and are predicted to act as transcriptional activator hubsES hotspots are preferentially occupied by activators. A. Overlap of genes in three groups in ES Ng dataset with up- and down-regulated genes upon Oct4 knockdown in ES cells showing hotspots were enriched for only down-regulated genes. B. Fraction of up- and down-regulated genes upon Dnmt and Set1db knock out in three groups in ES Ng dataset showing hotspot enrichment only in Set1db KO down-regulated genes.Back to article page