Amyloid precursor protein interaction network in human testis: sentinel proteins for male reproduction

BMC Bioinformatics

Table 2 Enriched GO categories for each module of the extended network

M	Most significant biological process			Most significant cellular component
M	GO term	p value	%	GO term	p value	%
4	Cell cycle	2.7E-82	60.2	Cytosol	4.3E-41	48.8
4	Regulation of ubiquitin-protein ligase activity during mitotic cell cycle	1.3E-130	41.0	Proteasome complex	1.9E-67	25.3
5	DNA metabolic process	1.2E-88	45.0	Nuclear lumen	2.1E-56	48.6
5	DNA metabolic process	1.2E-88	45.0	Nucleoplasm	8.7E-66	44.1
7	Microtubule-based process	3.8E-40	40.0	Microtubule cytoskeleton	6.1E-68	70.8
7	Microtubule-based process	3.8E-40	40.0	Centrosome	3.8E-70	58.4
10	Cell cycle	6.6E-20	47.2	Chromosomal part	1.2E-19	39.6
10	Cell cycle	6.6E-20	47.2	Chromosome, centromeric region	7.9E-26	35.8
11	G-protein coupled receptor protein signaling pathway	9.5E-141	63.1	Plasma membrane	4.3E-45	65.1
12	Modification-dependent protein catabolic process	1.7E-16	40.4	Endoplasmic reticulum	4.2E-9	32.7

Only modules with at least 40.0% of the proteins sharing a biological function are represented. M, modularity.

ISSN: 1471-2105