Table 2 Prediction of repeat regions for a representative set of 15 proteins compared with UniProt annotation, RADAR and ConSole output
From: Identifying tandem Ankyrin repeats in protein structures
| Protein name | PDB (chain) | UniProt annotation | RADAR | ConSole | AnkPred |
|---|---|---|---|---|---|
| 3ANK | 1N0Q (A) | - | 3-35, 36–68, 69-92 | 21-52 | 3-33, 34–67, 68-93 |
| 4ANK | 1N0R (A) | - | 1-33, 34–66, 67–99, 100-125 | 21-52, 53-84 | 1-33, 34–66, 67–100, 101-126 |
| Protein phosphatase 1 regulatory subunit 12A | 1S70 (B) | 39-68, 72–101, 105–134, 138–164, 198–227, 231-260 | 47-73, 77–106, 110–139, 203–232, 236-265 | 44-74, 75–105, 106–136, 137–167, 175–205, 206–236, 237-267 | 36-71, 72–104, 105–138, 198–231, 232-267 |
| Mouse GABP α/βdomain | 1AWC (B) | 5-34, 37–66, 70–99, 103–132, 136-166 | 13-34, 40–67, 73–100, 106-133 | 16-47, 48–79, 80-111 | 5-36, 37–69, 70–103, 104–136, 137-157 |
| TRPV6 Ankyrin repeat domain | 2RFA (A) | 44-74, 78–107, 116–145, 162–191, 195–236, 238-267 | 46-91, 93–129, 164-208 | 117-132 | 44-77, 78–114, 116–142, 162–194, 195–237, 238-265 |
| Yeast Nas6p complex with proteasome subunit, rpt3 | 2DZN (A) | 1-30, 35–64, 71–100, 106–135, 139–168, 173-203 | 5-37, 38–70, 74–106, 109–141, 142-175 | 13-44, 45–76, 77–108, 112–143, 144–175, 176-207 | 3-34, 35–70, 71–105, 106–138, 139–172, 173–207, 208-228 |
| D34 of human Ankyrin-R | 1 N11 (A) | 403-432, 436–465, 469–498, 502–531, 535–564, 568–597, 601–630, 634–663, 667–696, 700–729, 733–762, 766-795 | 406-431, 438–458, 471–487, 504–530, 537–563, 570–596, 603–629, 636–662, 669–695, 702–728, 735-761 | 415-446, 447–478, 479–510, 511–542, 543–574, 575–606, 607–638, 639–670, 671–702, 703–734, 735–766, 767-802 | 405-432, 436–458, 469–487, 503–535, 536–567, 568–600, 601–633, 634–666, 667–699, 700–733, 734–766, 767-796 |
| Human gankyrin | 1UOH (A) | 3-36, 37–69, 70–102, 103–135, 136–168, 169–201, 202-226 | 49-78, 82–111, 115–144, 148–177, 181-210 | 23-53, 54–84, 85–115, 116–146, 147–177, 178-208 | 5-38, 39–71, 72–105, 106–137, 138–170, 171–204, 205-226 |
| P53-53BP2 complex | 1YCS (B) | 958-990, 991-1023 | 959-987, 992-1020 | 337-352, 398-413 | 926-957, 958–990, 991–1024, 1025-1067 |
| Tumor Suppressor P15(INK4B) | 1D9S (A) | 5-34, 38–66, 71–100, 104-130 | 24-44, 56–86, 88-119 | 78-111 | 71-104, 105-129 |
| Notch | 2F8Y (A) | 1927-1956, 1960–1990, 1994–2023, 2027–2056, 2060-2089 | 1884-1930, 1931–1963, 1964–1997, 1998–2030, 2031–2063, 2064-2096 | 1919-1950, 1951–1982, 1983–2014, 2015–2046, 2047–2078, 2079-2110 | 1928-1960, 1961–1994, 1995–2027, 2028–2060, 2061–2094, 2095-2122 |
| S. Cerevisiae Swi6 Ankyrin repeat fragmen | 1SW6 (A) | 318-346, 347–383, 384–469, 470–498, 499-514 | 348-391, 467-507 | 316-323, 324–331, 470-477 | - |
| Human Osteoclast Stimulating Factor | 3EHQ (A) | 72-101, 105–135, 139-168 | 94-126, 128-159 | 83-114, 115–147, 148-180 | 72-104, 105–138, 139-177 |
| Ankyrin repeat domain of Huntingtin interacting protein 14 | 3EU9 (A) | 89-118, 123–155, 156–188, 189–219, 224-253 | 64-90, 94–123, 128–157, 161–190, 194–225, 229-252 | 70-101, 102–133, 134–165, 166–197, 198–229, 230-261 | 57-88, 89–122, 123–156, 157–189, 190–223, 224–257, 258-281 |
| ANKRA | 3SO8 (A) | 148-180, 181–213, 214–246, 247–279, 280-313 | 34-89, 100-155 | 29-60, 61–92, 93–124, 125-156 | 149-180, 181–213, 214–246, 247–280, 281-310 |