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Table 1 Sensitivity of ViVaMBC in plasmid experiment

From: ViVaMBC: estimating viral sequence variation in complex populations from illumina deep-sequencing data using model-based clustering

Mixing prop 36 ATG (%) 155 AAA (%)
1:200 0.45 0.42
1:100 0.92 0.91
1:50 2.28 2.20
1:10 11.04 10.01
  1. Two HCV-plasmids which differ at two codon positions 36 and 155 were combined in a sample for Illumina deep sequencing at four different mixing proportions. Their frequencies were estimated with ViVaMBC, which was able to retrieve codon variants with frequencies up to 0.5%.