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Table 1 Sensitivity of ViVaMBC in plasmid experiment

From: ViVaMBC: estimating viral sequence variation in complex populations from illumina deep-sequencing data using model-based clustering

Mixing prop

36 ATG (%)

155 AAA (%)

1:200

0.45

0.42

1:100

0.92

0.91

1:50

2.28

2.20

1:10

11.04

10.01

  1. Two HCV-plasmids which differ at two codon positions 36 and 155 were combined in a sample for Illumina deep sequencing at four different mixing proportions. Their frequencies were estimated with ViVaMBC, which was able to retrieve codon variants with frequencies up to 0.5%.
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BMC Bioinformatics

ISSN: 1471-2105

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