Figure 4From: Inferring dynamic gene regulatory networks in cardiac differentiation through the integration of multi-dimensional data Inferring dynamic networks during cardiac differentiation by a time-varying dynamic Bayesian network model. (A) Number of inferred gene-gene regulatory relationships in ESC-MES, MES-CPs, and CPs-CMs transitions. (B) Number of predicted transcription factor binding sites that are overlapped with known ESC and heart enhancers on genes that have enhancers within their 2Â kb, 10Â kb or 40Â kb regions surrounding the transcriptional start sites. (C) Predicted up- or down-regulated genes on computationally inducing Pou5f1 five-fold in ESCs compared with known up- or down-regulated genes on experimentally inducing Pou5f1. p-values were determined using Fisher's exact test.Back to article page