Inferring dynamic networks during cardiac differentiation by a time-varying dynamic Bayesian network model. (A) Number of inferred gene-gene regulatory relationships in ESC-MES, MES-CPs, and CPs-CMs transitions. (B) Number of predicted transcription factor binding sites that are overlapped with known ESC and heart enhancers on genes that have enhancers within their 2 kb, 10 kb or 40 kb regions surrounding the transcriptional start sites. (C) Predicted up- or down-regulated genes on computationally inducing Pou5f1 five-fold in ESCs compared with known up- or down-regulated genes on experimentally inducing Pou5f1. p-values were determined using Fisher's exact test.