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Figure 4 | BMC Bioinformatics

Figure 4

From: Inferring dynamic gene regulatory networks in cardiac differentiation through the integration of multi-dimensional data

Figure 4

Inferring dynamic networks during cardiac differentiation by a time-varying dynamic Bayesian network model. (A) Number of inferred gene-gene regulatory relationships in ESC-MES, MES-CPs, and CPs-CMs transitions. (B) Number of predicted transcription factor binding sites that are overlapped with known ESC and heart enhancers on genes that have enhancers within their 2 kb, 10 kb or 40 kb regions surrounding the transcriptional start sites. (C) Predicted up- or down-regulated genes on computationally inducing Pou5f1 five-fold in ESCs compared with known up- or down-regulated genes on experimentally inducing Pou5f1. p-values were determined using Fisher's exact test.

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