Performance comparison on yeast genetic interaction data. Cumulative distributions of NETSIM-based gene similarity scores of positive (A) and negative (B) genetic interactions in yeast. The blue line represents randomly selected ‘non-interaction’ pairs. The red line represents positive or negative genetic interactions. Correlation between NETSIM-based gene similarity scores and positive (C) or negative (D) genetic interactions in yeast. In C and D, the y-axis is percentage of genetic interaction pairs in the selected gene pairs with their NETSIM scores larger than a given threshold which varies in the x-axis. The red line is the polynomial model fitting line.