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Table 4 Distribution of CpG islands in HBV genotypes A-G

From: Mutations and CpG islands among hepatitis B virus genotypes in Europe

Genotype Three-conventional CpG islands Two-conventional CpG islands Novel CpG islands
number % number % number %
A total 115 76.66% 31 20.67% 4 2.67%
(n = 150)
A normal 100 81.30% 21 17.07% 2 1.63%
(n = 123)
A mutant 15 55.56% 10 37.04% 2 7.40%
(n = 27)
B total 4 66.7% 2 33.3% 0 0
(n = 6)
B normal 4 66.7% 2 33.3% 0 0
(n = 6)
B mutant 0 0 0 0 0 0
(n = 0)
C total 1 100% 0 0 0 0
(n = 1)
C normal 1 100% 0 0 0 0
(n = 1)
C mutant 0 0 0 0 0 0
(n = 0)
D total 135 68.53% 59 29.95% 3 1.52%
(n = 197)*
D normal 71 66.98% 34 32.08% 1 0.94%
(n = 106)
D mutant 64 70.33% 25 27.47% 2 2.20%
(n = 91)*
E total 8 61.54% 3 23.08% 2 15.38%
(n = 13)*
E normal 8 66.66% 2 16.67% 2 16.67%
(n = 12)
E mutant 0 0 1 100% 0 0
(n = 1)*
F total 0 0 2 100% 2 100%
(n = 2)
F normal 0 0 2 100% 2 100%
(n = 2)
F mutant 0 0 0 0 0 0
(n = 0)
G total 0 0 11 100% 0 0
(n = 11)
G normal 0 0 6 100% 0 0
(n = 6)
G mutant 0 0 5 100% 0 0
(n = 5)
Sum 263 69.21% 108 28.42% 11** 2.89%
  1. *In a total 383 isolates, three (two mutant isolates from genotype D and one from E) lacked both CpG island I and III, which were excluded from the distribution analysis.
  2. **Of the remaining 380 isolates, two normal isolates of genotype F contained both two-conventional islands and novel island V, which were used twice for calculating the rates.