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Table 1 Empirical type-I error estimates in the absence of population substructure

From: Family-based association analysis: a fast and efficient method of multivariate association analysis with multiple variants

    α
TYPE Q D ' 0.005 0.01 0.05
Quantitative 2 0 0.0056 0.0105 0.0481
2 0.5 0.0043 0.0091 0.0482
5 0 0.0059 0.0115 0.0506
5 0.5 0.0044 0.0103 0.0526
Dichotomous 2 0 0.0038 0.0088 0.0455
2 0.5 0.0039 0.0095 0.0502
5 0 0.0041 0.0083 0.0509
5 0.5 0.0056 0.0098 0.0501
  1. The empirical type-I errors were estimated with 10,000 replicates at several significance levels. We assumed that the number of markers is two, and that their minor allele frequencies were generated as U(0.1, 0.4). ρ was assumed to be 0.2.