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Table 1 Empirical type-I error estimates in the absence of population substructure

From: Family-based association analysis: a fast and efficient method of multivariate association analysis with multiple variants

   

α

TYPE

Q

D '

0.005

0.01

0.05

Quantitative

2

0

0.0056

0.0105

0.0481

2

0.5

0.0043

0.0091

0.0482

5

0

0.0059

0.0115

0.0506

5

0.5

0.0044

0.0103

0.0526

Dichotomous

2

0

0.0038

0.0088

0.0455

2

0.5

0.0039

0.0095

0.0502

5

0

0.0041

0.0083

0.0509

5

0.5

0.0056

0.0098

0.0501

  1. The empirical type-I errors were estimated with 10,000 replicates at several significance levels. We assumed that the number of markers is two, and that their minor allele frequencies were generated as U(0.1, 0.4). ρ was assumed to be 0.2.