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Table 4 Empirical power estimates for quantitative phenotypes in the presence of population substructure

From: Family-based association analysis: a fast and efficient method of multivariate association analysis with multiple variants

FST

ρ

Q

D '

MMASTOR

MFBAT

MFQLS

0.01

0.2

2

0

0.5020

0.1935

0.5680

2

0.5

0.6860

0.3530

0.7570

5

0

0.7380

0.3610

0.7965

5

0.5

0.9065

0.6430

0.9180

0.5

2

0

0.4765

0.1630

0.5300

2

0.5

0.6710

0.3365

0.7390

5

0

0.6820

0.2990

0.6975

5

0.5

0.8450

0.5057

0.8600

0.05

0.2

2

0

0.4880

0.1925

0.5330

2

0.5

0.6550

0.3250

0.6925

5

0

0.7210

0.3465

0.7375

5

0.5

0.8765

0.6430

0.8885

0.5

2

0

0.4555

0.1620

0.4830

2

0.5

0.6335

0.3150

0.6745

5

0

0.6525

0.2995

0.6570

5

0.5

0.8160

0.4850

0.8190

  1. The empirical power was estimated using 2,000 replicates at the 0.005 significance level. We assumed that the number of markers was two, and that their minor allele frequencies were generated as U(0.1, 0.5).
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BMC Bioinformatics

ISSN: 1471-2105

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