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Table 5 Empirical power estimates for dichotomous phenotypes in the presence of population substructure

From: Family-based association analysis: a fast and efficient method of multivariate association analysis with multiple variants

FST ρ Q D ' MMQLS MFBAT MFQLS
0.01 0.2 2 0 0.2075 0.0565 0.2350
2 0.5 0.3365 0.1135 0.3795
5 0 0.3455 0.0975 0.3825
5 0.5 0.6025 0.2330 0.6455
0.5 2 0 0.1830 0.0545 0.2140
2 0.5 0.2900 0.1165 0.3120
5 0 0.2855 0.0910 0.3240
5 0.5 0.5345 0.2200 0.5965
0.05 0.2 2 0 0.1975 0.0575 0.2300
2 0.5 0.2840 0.0995 0.3210
5 0 0.2990 0.0915 0.3335
5 0.5 0.5405 0.2140 0.5860
0.5 2 0 0.1680 0.0595 0.2065
2 0.5 0.2605 0.1095 0.2930
5 0 0.2620 0.0910 0.3025
5 0.5 0.4835 0.1800 0.5370
  1. The empirical power was estimated using 2,000 replicates at the 0.005 significance level. We assumed that the number of markers was 2, and that their minor allele frequencies were 0.2.