Figure 1
From: The effect of rare variants on inflation of the test statistics in case–control analyses
The level of inflation of the median test statistic for variants, with increasing numbers of heterozygotes, in a case–control analysis using the likelihood ratio test, the Wald test and the score test. a) The over-dispersion ratio at the median test statistic in a case–control analysis for a sample size of 5,000 with up to 50 heterozygotes. b) The over-dispersion ratio at the median test statistic in a case–control analysis for a sample size of 10,000 with up to 50 heterozygotes.