Figure 2
From: The effect of rare variants on inflation of the test statistics in case–control analyses
The level of inflation in the test statistic evaluated at the mean is used to smooth out the variation in the median test statistic caused by the small number of contingencies. We consider how the over-dispersion ratio varies as the frequency of variant increases. a) The over-dispersion ratio evaluated at the mean test statistic in a case–control analysis of 5,000 samples with variants with up to 50 heterozygotes. b) The over-dispersion ratio evaluated at the mean test statistic in a case–control analysis of 10,000 samples with variants with up to 50 heterozygotes.