Table 1 Positive feedback loops in the network of Figure 2

1

CDK-1/CYB-3 →

2

LIN-12i →

3

LIN-39 →

4

CDK-4/CYD-1 ⊣ CKI-1 ⊣

5

CDK-2/CYE-1 ⊣ LIN-35 ⊣

6

LIN-12i → LIN-12m →

7

CDK-4/CYD-1 ⊣ CDK-1/CYB-3 ⊣

8

SCF ⊣ APC ⊣

9

CDK-2/CYE-1 ⊣ LIN-35 ⊣ EFL-1 →

10

LIN-12i ⊣ MPK-1 ⊣ LIN-12m →

11

CDK-4/CYD-1 ⊣ CDK-1/CYB-3 → CKI-1 ⊣

12

CDK-4/CYD-1 ⊣ CDK-1/CYB-3 → APC → CKI-1 ⊣

13

SCF ⊣ APC → CKI-1 ⊣ CDK-2/CYE-1 →

14

CKI-1 ⊣ CDK-2/CYE-1 → LIN-12i ⊣ MPK-1 ⊣

15

CKI-1 ⊣ CDK-1/CYB-3 ⊣ LIN-12i ⊣ MPK-1 ⊣

16

SCF ⊣ CDK-4/CYD-1 ⊣ CKI-1 ⊣ CDK-1/CYB-3 → APC ⊣

17

SCF ⊣ CDK-2/CYE-1 → LIN-12i ⊣ MPK-1 → LIN-39 →

18

SCF ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-1/CYB-3 → APC ⊣

19

SCF ⊣ CDK-4/CYD-1 → LIN-12m → LIN-12i ⊣ MPK-1 → LIN-39 →

20

SCF ⊣ CDK-4/CYD-1 ⊣ CDK-1/CYB-3 ⊣ LIN-12i ⊣ MPK-1 →

LIN-39 →

21

SCF ⊣ APC → CKI-1 ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣ CDK-2/CYE-1 →

22

SCF ⊣ APC ⊣ CDK-1/CYB-3 ⊣ LIN-12i ⊣ MPK-1 → LIN-39 →

23

SCF ⊣ CDK-2/CYE-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-1/CYB-3 → APC ⊣

24

CKI-1 ⊣ CDK-1/CYB-3 ⊣ CDK-4/CYD-1 → LIN-12m → LIN-12i ⊣

MPK-1 ⊣

25

CKI-1 ⊣ CDK-4/CYD-1 ⊣ LIN-35 → CDK-2/CYE-1 → LIN-12i ⊣

MPK-1 ⊣

26

SCF ⊣ CDK-4/CYD-1 ⊣ CDK-1/CYB-3 ⊣ LIN-12i ⊣ MPK-1 ⊣ CKI-1 ⊣

CDK-2/CYE-1 →

27

SCF ⊣ CDK-4/CYD-1 ⊣ CKI-1 ⊣ CDK-2/CYE-1 → LIN-12i ⊣

MPK-1 → LIN-39 →

28

SCF ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣ CDK-2/CYE-1 → LIN-12i ⊣

MPK-1 → LIN-39 →

29

SCF ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-1/CYB-3 → CKI-1 ⊣

CDK-2/CYE-1 →

30

SCF ⊣ APC → CKI-1 ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣ EFL-1 →

CDK-2/CYE-1 →

31

SCF ⊣ APC → CKI-1 ⊣ CDK-1/CYB-3 ⊣ LIN-12i ⊣ MPK-1 →

LIN-39 →

32

SCF ⊣ CDK-4/CYD-1 → LIN-12m → LIN-12i ⊣ MPK-1 ⊣ CKI-1 ⊣

CDK-2/CYE-1 →

33

SCF ⊣ APC ⊣ CDK-1/CYB-3 ⊣ LIN-12i ⊣ MPK-1 ⊣ CKI-1 ⊣

CDK-2/CYE-1 →

34

CKI-1 ⊣ CDK-2/CYE-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-1/CYB-3 ⊣

LIN-12i ⊣ MPK-1 ⊣

35

CKI-1 ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-1/CYB-3 ⊣

LIN-12i ⊣ MPK-1 ⊣

36

SCF ⊣ CDK-4/CYD-1 ⊣ CKI-1 ⊣ CDK-2/CYE-1 ⊣ LIN-35 ⊣ EFL-1 →

CDK-1/CYB-3 → APC ⊣

37

SCF ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-2/CYE-1 →

LIN-12i ⊣ MPK-1 → LIN-39 →

38

SCF ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-1/CYB-3 → APC →

CKI-1 ⊣ CDK-2/CYE-1 →

39

SCF ⊣ CDK-4/CYD-1 ⊣ CDK-1/CYB-3 → CKI-1 ⊣ CDK-2/CYE-1 →

LIN-12i ⊣ MPK-1 → LIN-39 →

40

SCF ⊣ APC ⊣ CDK-1/CYB-3 ⊣ CDK-4/CYD-1 → LIN-12m →

LIN-12i ⊣ MPK-1 → LIN-39 →

41

SCF ⊣ APC ⊣ CDK-1/CYB-3 → CKI-1 ⊣ CDK-2/CYE-1 → LIN-12i ⊣

MPK-1 → LIN-39 →

42

CKI-1 ⊣ CDK-1/CYB-3 ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣ EFL-1 →

CDK-2/CYE-1 → LIN-12i ⊣ MPK-1 ⊣

43

SCF ⊣ CDK-2/CYE-1 → LIN-12i ⊣ MPK-1 ⊣ CKI-1 ⊣ CDK-4/CYD-1 ⊣

CDK-1/CYB-3 → APC ⊣

44

SCF ⊣ CDK-4/CYD-1 ⊣ CDK-1/CYB-3 → APC → CKI-1 ⊣

CDK-2/CYE-1 → LIN-12i ⊣ MPK-1 → LIN-39 →

45

CKI-1 ⊣ CDK-2/CYE-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-1/CYB-3 ⊣

CDK-4/CYD-1 → LIN-12m → LIN-12i ⊣ MPK-1 ⊣

46

SCF ⊣ APC → CKI-1 ⊣ CDK-1/CYB-3 ⊣ CDK-4/CYD-1 → LIN-12m →

LIN-12i ⊣ MPK-1 → LIN-39 →

47

SCF ⊣ APC ⊣ CDK-1/CYB-3 ⊣ CDK-4/CYD-1 → LIN-12m → LIN-12i

⊣ MPK-1 ⊣ CKI-1 ⊣ CDK-2/CYE-1 →

48

SCF ⊣ CDK-4/CYD-1 ⊣ LIN-35 → CDK-2/CYE-1 → LIN-12i ⊣ MPK-1

⊣ CKI-1 ⊣ CDK-1/CYB-3 → APC ⊣

49

SCF ⊣ APC ⊣ CDK-1/CYB-3 ⊣ CDK-4/CYD-1 ⊣ CKI-1 ⊣ CDK-2/CYE-1

→ LIN-12i ⊣ MPK-1 → LIN-39 →

50

SCF ⊣ APC ⊣ CDK-1/CYB-3 ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣ CDK-2/CYE-1

→ LIN-12i ⊣ MPK-1 → LIN-39 →

51

SCF ⊣ APC ⊣ CDK-1/CYB-3 → CKI-1 ⊣ CDK-4/CYD-1 → LIN-12m →

LIN-12i ⊣ MPK-1 → LIN-39 →

52

SCF ⊣ APC ⊣ CDK-1/CYB-3 ⊣ LIN-12i ⊣ MPK-1 ⊣ CKI-1 ⊣

CDK-4/CYD-1 ⊣ LIN-35 ⊣ EFL-1 → CDK-2/CYE-1 →

53

SCF ⊣ APC → CKI-1 ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣ EFL-1 →

CDK-1/CYB-3 ⊣ LIN-12i ⊣ MPK-1 → LIN-39 →

54

SCF ⊣ APC → CKI-1 ⊣ CDK-2/CYE-1 ⊣ LIN-35 ⊣ EFL-1 →

CDK-1/CYB-3 ⊣ LIN-12i ⊣ MPK-1 → LIN-39 →

55

SCF ⊣ APC → CKI-1 ⊣ CDK-1/CYB-3 ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣

CDK-2/CYE-1 → LIN-12i ⊣ MPK-1 → LIN-39 →

56

SCF ⊣ APC ⊣ CDK-1/CYB-3 ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣ EFL-1 →

CDK-2/CYE-1 → LIN-12i ⊣ MPK-1 → LIN-39 →

57

SCF ⊣ APC ⊣ CDK-1/CYB-3 → CKI-1 ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣

CDK-2/CYE-1 → LIN-12i ⊣ MPK-1 → LIN-39 →

58

SCF ⊣ APC → CKI-1 ⊣ CDK-1/CYB-3 ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣

EFL-1 → CDK-2/CYE-1 → LIN-12i ⊣ MPK-1 → LIN-39 →

59

SCF ⊣ APC ⊣ CDK-1/CYB-3 → CKI-1 ⊣ CDK-4/CYD-1 ⊣ LIN-35 ⊣

EFL-1 → CDK-2/CYE-1 → LIN-12i ⊣ MPK-1 → LIN-39 →

60

SCF ⊣ APC → CKI-1 ⊣ CDK-2/CYE-1 ⊣ LIN-35 ⊣ EFL-1 →

CDK-1/CYB-3 ⊣ CDK-4/CYD-1 → LIN-12m → LIN-12i ⊣ MPK-1 →

LIN-39 →