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Figure 5 | BMC Bioinformatics

Figure 5

From: DomSign: a top-down annotation pipeline to enlarge enzyme space in the protein universe

Figure 5

Expansion of enzyme space in UniProt-TrEMBL and KEGG by DomSign (specificity threshold = 80%). (A) Expansion of enzyme space in UniProt-TrEMBL. The circles illustrate the distribution of three kinds of proteins in the TrEMBL database. Blue: enzymes already tagged with EC numbers in TrEMBL; red: novel enzymes exclusively predicted by DomSign; light orange: other proteins without EC numbers. The column on the right represents the ratio of EC hierarchy levels among predicted novel enzymes by DomSign. Straight line: predicted enzymes annotated as EC = x.-.-.-; blank: annotated as EC = x.x.-.-; dot: annotated as EC = x.x.x.-; slash: annotated as EC = x.x.x.x. (B) Expansion of enzyme space in KEGG. Each blue dot represents the original enzyme ratio for one particular bacteria genome in KEGG. Each red dot represents the total enzyme ratio for one particular bacteria genome after DomSign annotation. In total, 2,584 bacterial genomes were tested.

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